Ellen’s best friend, Jen, has been a show regular since day one. Watch some of Jennifer Aniston’s best moments on the show from hilarious rounds of "Heads Up!" to spilling secrets on "Burning Questions."

00:00 Intro

00:11 How Ellen Got Into the White House

01:09 Head's Up

02:44 Ellen's Best Friend

04:25 Jen Gets Scared by Ellen

06:33 12 Days of Giveaways

08:26 Burning Questions

09:22 Jen's Birthday